Certican 0.75mg (60 Tablets)

Manufacturer	Novartis Pharma Pakistan
Active Ingredients	Everolimus
Medicine Strength	0.75mg per Tablet
Formulation	Film-Coated Tablets
Requires Prescription?	Yes (Transplant Specialist prescription required)
Generics	Everolimus

Certican Ingredients and Usage

The active ingredient is Everolimus, an mTOR inhibitor derived from sirolimus. The 0.75mg tablets are taken orally twice daily for transplant rejection prophylaxis. Certican is clinically indicated for:

• Kidney and heart transplant rejection prevention
• Prophylaxis of organ rejection in adult patients
• Combination therapy with cyclosporine and corticosteroids

How Does Certican Work?

Certican provides immunosuppression through mTOR pathway inhibition:

1. mTOR Inhibition: Blocks mammalian target of rapamycin pathway
2. Cell Cycle Arrest: Prevents T-lymphocyte activation and proliferation
3. Antiproliferative Effect: Inhibits growth factor-driven cell division
4. Selective Action: Targets specific immune response pathways

Certican Side Effects and Warnings

Common side effects include edema, hyperlipidemia, hypertension, urinary tract infections, and anemia. Most effects are manageable with dose adjustment.

Serious Considerations

1. Increased Infection Risk: Higher susceptibility to bacterial and viral infections
2. Malignancy Risk: Increased incidence of lymphoma and skin cancer
3. Renal Impairment: May worsen kidney function - monitor regularly
4. Drug Interactions: Strong CYP3A4 inhibitors increase everolimus levels
5. Pregnancy Risk: Category C - avoid in pregnancy without contraception

Certican Storage Conditions

Certican Tablets require proper storage conditions:

• Store at room temperature below 25°C
• Keep in original blister packaging
• Protect from moisture and light
• Keep out of reach of children
• Do not use after expiration date