Clavir 60mg Tablets 28S

Manufacturer	Hilton Pharma
Active Ingredients	Daclatasvir Dihydrochloride
Medicine Strength	60mg per Tablet
Formulation	Film-Coated Tablets
Requires Prescription?	Yes (Gastroenterologist/Hepatologist prescription)
Generics	Daclatasvir

Clavir Ingredients and Usage

The active ingredient is Daclatasvir Dihydrochloride, an NS5A replication complex inhibitor. The 60mg tablet is taken once daily with or without food in combination with other antivirals. Clavir is clinically indicated for:

• Chronic hepatitis C genotype 1, 2, 3 and 4 infections
• Treatment-naïve and treatment-experienced patients
• Combination therapy with sofosbuvir or other DAAs
• Patients with compensated liver disease including cirrhosis

How Does Clavir Work?

Clavir provides targeted antiviral action through specific mechanisms:

1. NS5A Inhibition: Blocks hepatitis C virus NS5A phosphoprotein function
2. Viral Replication Suppression: Prevents viral RNA replication and virion assembly
3. Multi-genotypic Activity: Effective against multiple hepatitis C genotypes
4. High Barrier to Resistance: Maintains efficacy despite viral mutations

Clavir Side Effects and Warnings

Common side effects include headache, fatigue, nausea, and diarrhea. Most reactions are mild and transient during treatment.

Serious Considerations

1. Drug Interactions: Strong CYP3A inducers reduce daclatasvir levels
2. Hepatitis B Reactivation: Screen for HBV coinfection before treatment
3. Bradycardia Risk: When used with amiodarone and sofosbuvir
4. Renal Impairment: No dose adjustment needed in kidney disease
5. Treatment Duration: Varies based on genotype and prior treatment history

Clavir Storage Conditions

Clavir Tablets require proper storage conditions:

• Store at room temperature below 30°C
• Keep in original packaging protected from moisture
• Protect from light and excessive heat
• Keep out of reach of children
• Do not use after expiration date