Colimate Injection (1 MIU)

(0 reviews)

₨700 ₨1,036 Save ₨336

<p>Colimate Injection contains Colistimethate Sodium for multidrug-resistant Gram-negative infections. Buy Colimate 1 MIU Injection online at PakMeds for critical infection management.</p>

SKU: A101 Out of Stock

100% Authentic

Fast Delivery

Easy Returns

Manufacturer	Atco Laboratories Pakistan
Active Ingredients	Colistimethate Sodium
Medicine Strength	1 Million International Units per vial
Formulation	Powder for Solution for Intravenous/Inhalation Use
Requires Prescription?	Yes (Hospital/Critical Care use only)
Generics	Colistimethate Sodium

Colimate Ingredients and Usage

The active ingredient is Colistimethate Sodium, a polymyxin E antibiotic. The 1 MIU powder requires reconstitution for intravenous infusion or nebulizer administration.

Colimate is clinically indicated for:

Multidrug-resistant Pseudomonas aeruginosa infections
Carbapenem-resistant Enterobacteriaceae infections
Ventilator-associated pneumonia treatment
Cystic fibrosis pulmonary exacerbations

How Does Colimate Work?

Colimate provides bactericidal action through membrane disruption:

Membrane Permeabilization: Binds to bacterial outer membrane lipopolysaccharides
Cellular Content Leakage: Causes osmotic imbalance and cell death
Rapid Bacterial Killing: Exhibits concentration-dependent killing
Biofilm Penetration: Effective against biofilm-forming bacteria

Colimate Side Effects and Warnings

Common side effects include nephrotoxicity, neurotoxicity, and bronchospasm during inhalation. Most effects are dose-dependent and reversible.

Serious Considerations

Nephrotoxicity: Requires frequent renal function monitoring
Neuromuscular Blockade: May cause respiratory muscle weakness
Dosing Calculation: Based on ideal body weight and renal function
Drug Interactions: Enhanced toxicity with aminoglycosides
Loading Dose: Essential for achieving therapeutic levels quickly

Colimate Storage Conditions

Colimate Injection requires proper storage handling:

Store below 25°C protected from light
Use reconstituted solution within 24 hours if refrigerated
Protect from moisture and freezing
Discard if solution appears discolored or contains particles
Follow strict aseptic preparation techniques