Ecavir 0.5mg Tablet 30s

Manufacturer	Getz Pharma Pakistan
Active Ingredients	Entecavir
Medicine Strength	0.5mg per Tablet
Formulation	Film-Coated Tablets
Requires Prescription?	Yes (Gastroenterologist/Hepatologist prescription)
Generics	Entecavir

Ecavir Ingredients and Usage

The active ingredient is Entecavir, a guanosine nucleoside analogue. The 0.5mg tablet is taken once daily on an empty stomach at least 2 hours before or after food. Ecavir is clinically indicated for:

• Chronic hepatitis B virus infection in adults
• HBV replication-active liver disease
• Treatment-naïve patients with compensated liver disease
• Patients with elevated HBV DNA and ALT levels

How Does Ecavir Work?

Ecavir provides potent antiviral activity through selective HBV polymerase inhibition:

1. HBV Polymerase Inhibition: Competitively inhibits HBV reverse transcriptase
2. DNA Chain Termination: Incorporates into viral DNA causing chain termination
3. Viral Suppression: Reduces HBV DNA to undetectable levels
4. High Genetic Barrier: Low rate of resistance development

Ecavir Side Effects and Warnings

Common side effects include headache, fatigue, dizziness, and nausea. Most reactions are mild and transient.

Serious Considerations

1. Lactic Acidosis: Risk of severe lactic acidosis with hepatic steatosis
2. Hepatitis Exacerbation: Acute severe exacerbation upon discontinuation
3. Renal Impairment: Dose adjustment required in kidney dysfunction
4. HIV Coinfection: May select for HIV resistance if undiagnosed
5. Treatment Duration: Long-term therapy usually required

Ecavir Storage Conditions

Ecavir Tablets require proper storage conditions:

• Store at room temperature below 30°C
• Keep in original packaging protected from moisture
• Protect from light and excessive heat
• Keep out of reach of children
• Do not use after expiration date