Glivec 100mg Tabs. 90`s

Manufacturer	Novartis Pharma
Active Ingredients	Imatinib Mesylate
Medicine Strength	100mg per Tablet
Formulation	Film-Coated Tablets
Requires Prescription?	Yes (Oncologist or Hematologist prescription required)
Generics	Imatinib

Glivec Ingredients and Usage

The active ingredient is Imatinib Mesylate, a protein-tyrosine kinase inhibitor that specifically targets BCR-ABL tyrosine kinase. One 400mg tablet is taken once daily with a meal and large glass of water to minimize gastrointestinal irritation, with dosage adjustments based on disease type and response. Glivec is clinically indicated for:

• Newly diagnosed chronic myeloid leukemia (CML) in chronic phase
• CML in accelerated phase or blast crisis
• Kit (CD117)-positive gastrointestinal stromal tumors (GIST)
• Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
• Myelodysplastic/myeloproliferative diseases

How Does Glivec Work?

Glivec provides targeted anti-cancer action through specific kinase inhibition:

1. BCR-ABL Inhibition: Specifically inhibits BCR-ABL tyrosine kinase in CML cells
2. Kit Receptor Blockade: Inhibits Kit receptor tyrosine kinase in GIST tumors
3. PDGFR Inhibition: Blocks platelet-derived growth factor receptor activity
4. Selective Action: Targets abnormal kinases while sparing normal cellular functions

Glivec Side Effects and Warnings

Common side effects include edema, nausea, vomiting, muscle cramps, rash, fatigue, diarrhea, and hematological toxicity. Most adverse effects are manageable with dose adjustments and supportive care.

Serious Considerations

1. Fluid Retention: May cause severe fluid retention and pleural effusion
2. Hematologic Toxicity: Can cause severe neutropenia and thrombocytopenia
3. Hepatic Toxicity: May cause severe liver injury - monitor liver function regularly
4. Cardiac Toxicity: Risk of congestive heart failure and left ventricular dysfunction
5. Growth Retardation: May cause growth retardation in children and adolescents

Glivec Storage Conditions

Glivec Tablets require proper storage conditions:

• Store below 30°C in original container
• Keep the bottle tightly closed
• Protect from moisture and light
• Keep out of reach of children
• Do not use after expiration date