GTN 0.2% Ointment (Glyceryl Trinitrate)

Manufacturer	Various Pharmaceutical Companies
Active Ingredients	Glyceryl Trinitrate (Nitroglycerin)
Medicine Strength	0.2% w/w (2mg per gram)
Formulation	Topical Ointment
Requires Prescription?	Yes (Physician or Gastroenterologist prescription recommended)
Generics	Glyceryl Trinitrate, Nitroglycerin

GTN Ointment Ingredients and Usage

The active ingredient is Glyceryl Trinitrate, a nitric oxide donor that acts as a potent vasodilator. The ointment is applied topically to the anal canal 2-3 times daily, typically for 6-8 weeks, using a pea-sized amount (approximately 1-1.5cm) with appropriate applicator or finger cot. GTN Ointment is clinically indicated for:

• Chronic anal fissures unresponsive to conservative treatment
• Acute anal fissures with severe pain
• Anal sphincter spasm and hypertonia
• Post-operative anal pain management

How Does GTN Ointment Work?

GTN Ointment provides therapeutic effects through nitric oxide-mediated actions:

1. Smooth Muscle Relaxation: Releases nitric oxide causing internal anal sphincter relaxation
2. Blood Flow Improvement: Increases anodermal blood flow promoting fissure healing
3. Pain Reduction: Reduces anal resting pressure and associated pain
4. Healing Promotion: Enhances tissue perfusion and wound healing

GTN Ointment Side Effects and Warnings

Common side effects include headache, dizziness, lightheadedness, and local burning or irritation. Headaches typically diminish with continued use.

Serious Considerations

1. Hypotension: May cause systemic hypotension and syncope
2. Headache Management: Usually transient - may require dose adjustment
3. Cardiac Conditions: Use with caution in patients with cardiovascular disorders
4. PDE5 Inhibitors: Contraindicated with phosphodiesterase-5 inhibitors (sildenafil, tadalafil)
5. Pregnancy: Use during pregnancy only if clearly needed

GTN Ointment Storage Conditions

GTN Ointment requires proper storage conditions:

• Store below 25°C in original container
• Keep tube tightly closed
• Protect from light and moisture
• Keep out of reach of children
• Do not use after expiration date