Heparinol 5000IU Inj. 25`s

Manufacturer	Getz Pharma Pakistan
Active Ingredients	Heparin Sodium
Medicine Strength	5000 International Units per ml
Formulation	Solution for Subcutaneous/Intravenous Injection
Requires Prescription?	Yes (Hospital Use - Physician prescription required)
Generics	Heparin

Heparinol Ingredients and Usage

The active ingredient is Heparin Sodium, a glycosaminoglycan anticoagulant derived from porcine intestinal mucosa. It is administered by subcutaneous injection for prophylaxis or continuous intravenous infusion for treatment, with dosage adjusted based on activated partial thromboplastin time (aPTT) monitoring and clinical requirements. Heparinol is clinically indicated for:

• Prophylaxis of deep vein thrombosis (DVT) and pulmonary embolism
• Treatment of established venous thromboembolism
• Prevention of clotting during surgical procedures
• Maintenance of catheter patency in intravenous lines
• Treatment of acute coronary syndromes

How Does Heparinol Work?

Heparinol provides anticoagulant effects through enhanced inhibition of coagulation factors:

1. Antithrombin III Activation: Binds to antithrombin III, accelerating its activity
2. Thrombin Inhibition: Potently inactivates thrombin (Factor IIa)
3. Factor Xa Inhibition: Blocks Factor Xa in the coagulation cascade
4. Rapid Anticoagulation: Provides immediate effect with short duration of action

Heparinol Side Effects and Warnings

Common side effects include bleeding complications, heparin-induced thrombocytopenia, injection site reactions, and elevated liver enzymes. Most adverse effects are dose-dependent and manageable with proper monitoring.

Serious Considerations

1. Heparin-Induced Thrombocytopenia: Monitor platelet counts for HIT development
2. Bleeding Risk: High risk of hemorrhage - requires careful coagulation monitoring
3. Spinal Procedures: Contraindicated with recent spinal anesthesia or puncture
4. Osteoporosis: May cause bone density reduction with long-term use
5. Allergic Reactions: Possible hypersensitivity reactions in sensitive individuals

Heparinol Storage Conditions

Heparinol Injection requires proper storage conditions:

• Store below 25°C protected from light
• Keep vials in original packaging
• Protect from freezing
• Use immediately after opening
• Do not use if discolored or contains particles