Hepatitis B Immunoglobulin
<p>Hepatitis B Immunoglobulin contains specific antibodies against Hepatitis B virus, providing immediate passive immunity for post-exposure prophylaxis and prevention of Hepatitis B infection. Buy Hepatitis B Immunoglobulin at PakMeds for reliable post-exposure prevention and protection against Hepatitis B infection.</p>
| Manufacturer | Various Pharmaceutical Companies |
| Active Ingredients | Human Hepatitis B Immunoglobulin |
| Medicine Strength | 100-500 International Units per ml (various vial sizes) |
| Formulation | Solution for Intramuscular Injection |
| Requires Prescription? | Yes (Hospital/Clinic Administration - Physician prescription required) |
| Generics | HBIG, Hepatitis B Immune Globulin |
Hepatitis B Immunoglobulin Ingredients and Usage
The active ingredient is Human Hepatitis B Immunoglobulin, containing high titers of antibodies against Hepatitis B surface antigen (HBsAg). It is administered by deep intramuscular injection, typically in the gluteal region or deltoid muscle, as soon as possible after exposure and within 24 hours for optimal effectiveness.
Hepatitis B Immunoglobulin is clinically indicated for:
- Post-exposure prophylaxis following needlestick or sharps exposure to HBsAg-positive material
- Prevention of Hepatitis B infection in infants born to HBsAg-positive mothers
- Sexual partners of individuals with acute Hepatitis B infection
- Household contacts of individuals with acute Hepatitis B infection
- Liver transplant recipients with Hepatitis B
How Does Hepatitis B Immunoglobulin Work?
Hepatitis B Immunoglobulin provides immediate passive immunity through antibody transfer:
- Virus Neutralization: Provides ready-made antibodies that neutralize Hepatitis B virus
- Immediate Protection: Offers instant immunity while Hepatitis B vaccine develops active immunity
- Infection Prevention: Prevents establishment of Hepatitis B infection after exposure
- Bridge Protection: Protects during the critical period until vaccine-induced immunity develops
Hepatitis B Immunoglobulin Side Effects and Warnings
Common side effects include pain and tenderness at injection site, headache, fever, chills, and malaise. Most reactions are mild and transient.
Serious Considerations
- Anaphylaxis Risk: May cause severe allergic reactions in sensitive individuals
- IGA Deficiency: Contraindicated in patients with selective IgA deficiency
- Thrombocytopenia: Use with caution in patients with thrombocytopenia or bleeding disorders
- Vaccine Interference: Does not interfere with active immunization by Hepatitis B vaccine
- Multiple Injections: Large doses may require divided injections at different sites
Hepatitis B Immunoglobulin Storage Conditions
Hepatitis B Immunoglobulin requires strict storage conditions:
- Store at 2°C to 8°C in refrigerator
- Do not freeze - protect from light
- Keep in original carton until use
- Do not use if cloudy or contains particles
- Use immediately after opening
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