Hi-Sunate 120mg IV/IM Inj. 1`s

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Hi-Sunate Injection contains Artesunate, a potent water-soluble artemisinin derivative used for the treatment of severe and complicated malaria. Buy Hi-Sunate 120mg injections at PakMeds for effective emergency treatment of severe malaria cases.

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Manufacturer	Getz Pharma Pakistan
Active Ingredients	Artesunate
Medicine Strength	120mg per vial
Formulation	Powder for Solution for Intravenous/Intramuscular Injection
Requires Prescription?	Yes (Hospital Use - Physician prescription required)
Generics	Artesunate

Hi-Sunate Ingredients and Usage

The active ingredient is Artesunate, a water-soluble hemisuccinate derivative of artemisinin. The 120mg vial is reconstituted and administered by intravenous or intramuscular injection, typically given at 0, 12, 24, and 48 hours, followed by a complete course of oral ACT (Artemisinin-based Combination Therapy). Hi-Sunate is clinically indicated for:

Severe and complicated malaria caused by Plasmodium falciparum
Cerebral malaria with impaired consciousness
Acute renal failure due to malaria
Severe malarial anemia
Patients who cannot tolerate oral medication

How Does Hi-Sunate Work?

Hi-Sunate provides rapid antimalarial action through multiple mechanisms:

Free Radical Generation: Produces free radicals that damage parasite membranes
Hemozoin Inhibition: Interferes with hemozoin formation in malaria parasites
Rapid Parasite Clearance: Achieves rapid reduction of parasite biomass within hours
Broad Stage Specificity: Effective against all erythrocytic stages of malaria parasites

Hi-Sunate Side Effects and Warnings

Common side effects include transient fever, chills, headache, nausea, dizziness, and injection site reactions. Most adverse effects are mild and self-limiting.

Serious Considerations

Hemolytic Anemia: May cause delayed hemolytic anemia after treatment
Allergic Reactions: Can cause hypersensitivity reactions including anaphylaxis
Cardiac Effects: May cause QT interval prolongation on ECG
Hepatic Impairment: Use with caution in patients with liver dysfunction
Pregnancy: Consider risk-benefit ratio in pregnant women with severe malaria

Hi-Sunate Storage Conditions

Hi-Sunate Injection requires proper storage conditions:

Store unreconstituted vials below 30°C
Protect from light and moisture
Use reconstituted solution immediately
Do not freeze reconstituted solution
Discard unused portions appropriately